abstract：:In spite of the existence of pedunculopontine tegmental nucleus (PPTg) projections to cerebellar nuclei, their nature and functional role is unknown. These fibers may play a crucial role in postural control and may be involved in the beneficial effects induced by deep-brain stimulation (DBS) of brainstem structures in...

journal_title：Neuroscience

authors： Vitale F,Mattei C,Capozzo A,Pietrantoni I,Mazzone P,Scarnati E

更新日期：2016-03-11 00:00:00

abstract：:Post-traumatic syringomyelia (PTS) is a serious neurological disorder characterized by fluid filled cavities that develop in the spinal cord. PTS is thought to be caused by an imbalance between fluid inflow and outflow in the spinal cord, but the underlying mechanisms are unknown. The ion channel Kir4.1 plays an impor...

journal_title：Neuroscience

authors： Najafi E,Stoodley MA,Bilston LE,Hemley SJ

更新日期：2016-03-11 00:00:00

abstract：:The tectofugal pathway in birds consists of four stations, the retina, optic tectum, rotundal nucleus, and entopallium, and it conveys visual information via three ascending pathways. These pathways consist of retino-tectal, tecto-rotundal and rotundo-entopallial cells, all of which are glutamatergic. The present stud...

journal_title：Neuroscience

authors： Atoji Y

更新日期：2016-03-01 00:00:00

abstract：:Noninvasive functional imaging holds great promise for the future of translational research, due to the ability to directly compare between preclinical and clinical models of psychiatric disorders. Despite this potential, concerns have been raised regarding the necessity to anesthetize rodent and monkey subjects durin...

journal_title：Neuroscience

authors： Smith ML,Li J,Cote DM,Ryabinin AE

更新日期：2016-03-01 00:00:00

abstract：:Cholesterol is an essential substance for maintaining normal structure and function of the brain. But unfortunately, a long-term high-cholesterol diet can lead to a variety of pathological changes of the brain such as β-amyloid (Aβ) accumulation, Tau hyperphosphorylation, reactive gliosis, neuroinflammation, neuronal ...

journal_title：Neuroscience

authors： Chen YL,Wang LM,Chen Y,Gao JY,Marshall C,Cai ZY,Hu G,Xiao M

更新日期：2016-03-01 00:00:00

abstract：:The effects of intense noise exposure on the classical auditory pathway have been extensively investigated; however, little is known about the effects of noise-induced hearing loss on non-classical auditory areas in the brain such as the lateral amygdala (LA) and striatum (Str). To address this issue, we compared the ...

journal_title：Neuroscience

authors： Chen GD,Sheppard A,Salvi R

更新日期：2016-02-19 00:00:00

abstract：:Alzheimer's disease (AD) is one of the most common causes of dementia. Although the exact mechanisms of AD are not entirely clear, the impairment in adult hippocampal neurogenesis has been reported to play a role in AD. To assess the relationship between AD and neurogenesis, we studied APP/PS1/nestin-green fluorescent...

journal_title：Neuroscience

authors： Zeng Q,Zheng M,Zhang T,He G

更新日期：2016-02-09 00:00:00

abstract：:Central blockade of mineralocorticoid receptors (MRs) or angiotensin II type 1 receptors (AT1Rs) attenuates aldosterone (aldo)-salt induced hypertension. We examined the role of the subfornical organ (SFO), aldo synthesized locally in the brain, and MR and AT1R specifically in the paraventricular nucleus (PVN) in aldo...

journal_title：Neuroscience

authors： Wang HW,Huang BS,Chen A,Ahmad M,White RA,Leenen FH

更新日期：2016-02-09 00:00:00

abstract：:Experimental autoimmune encephalomyelitis (EAE) is a widely used animal model for the human disease multiple sclerosis (MS), a demyelinating and neurodegenerative pathology of the central nervous system. Both diseases share physiopathological and clinical characteristics, mainly associated with a neuroinflammatory pro...

journal_title：Neuroscience

authors： Chanaday NL,Roth GA

更新日期：2016-02-09 00:00:00

abstract：:Chronic psychosocial stress is an important environmental risk factor for the development of psychiatric diseases. However, studying the impact of chronic psychosocial stress in mice is time consuming and thus not optimally suited to 'screen' increasing numbers of genetically manipulated mouse models for psychiatric e...

journal_title：Neuroscience

authors： Brzózka MM,Unterbarnscheidt T,Schwab MH,Rossner MJ

更新日期：2016-02-09 00:00:00

abstract：:Repeated exposure to cocaine during adolescence may affect both physical and psychological conditions in the brain, and increase the risk of psychiatric disorders and addiction behaviors in adulthood. Adolescence represents a critical development period for the hippocampus. Moreover, different regions of the hippocamp...

journal_title：Neuroscience

authors： Zhu W,Mao Z,Zhu C,Li M,Cao C,Guan Y,Yuan J,Xie G,Guan X

更新日期：2016-01-28 00:00:00

abstract：:Delivering effective commands in the nervous systems require a temporal integration of neural activities such as synchronous firing. Although sympathetic nerve discharges are characterized by synchronous firing, its temporal structures and how it is modulated are largely unknown. This study used a collagenase-dissocia...

journal_title：Neuroscience

authors： Su CK

更新日期：2016-01-15 00:00:00

abstract：:Creatine supplementation has been shown to protect neurons from oxidative damage due to its antioxidant and ergogenic functions. These features have led to the hypothesis of creatine supplementation use during pregnancy as prophylactic treatment to prevent CNS damage, such as hypoxic-ischemic encephalopathy. Unfortuna...

journal_title：Neuroscience

authors： Sartini S,Lattanzi D,Ambrogini P,Di Palma M,Galati C,Savelli D,Polidori E,Calcabrini C,Rocchi MB,Sestili P,Cuppini R

更新日期：2016-01-15 00:00:00

abstract：:Brain responses to discrete short sounds have been studied intensively using the event-related potential (ERP) method, in which the electroencephalogram (EEG) signal is divided into epochs time-locked to stimuli of interest. Here we introduce and apply a novel technique which enables one to isolate ERPs in human elici...

journal_title：Neuroscience

authors： Poikonen H,Alluri V,Brattico E,Lartillot O,Tervaniemi M,Huotilainen M

更新日期：2016-01-15 00:00:00

abstract：:Cognitive deficits and psychotic symptoms are highly prevalent in patients with temporal lobe epilepsy (TLE). Imaging studies in humans have suggested that these comorbidities are associated with atrophy in temporal lobe structures and other limbic regions. It remains to be clarified whether TLE comorbidities are due ...

journal_title：Neuroscience

authors： Wolf DC,Bueno-Júnior LS,Lopes-Aguiar C,Do Val Da Silva RA,Kandratavicius L,Leite JP

更新日期：2016-01-15 00:00:00

abstract：:Previous studies have shown that nitric oxide can induce cysteine S-nitrosylation of total protein in synaptosomes, suggesting that nitric oxide may contribute to the regulation of synaptic protein function. Vesicular neurotransmitter transporters pack neurotransmitters into synaptic vesicles and play an important rol...

journal_title：Neuroscience

authors： Wang Y,Zhou Z,Leylek T,Tan H,Sun Y,Parkinson FE,Wang JF

更新日期：2015-12-17 00:00:00

abstract：:Microglia are the prime cellular sources of reactive oxygen species (ROS) in the central nervous system (CNS). Chronic activation of microglia has been linked to aging-associated neurodegenerative diseases such as Alzheimer's disease (AD) and Parkinson's disease (PD) since they produce excessive amounts of ROS for a p...

journal_title：Neuroscience

authors： Rangarajan P,Karthikeyan A,Lu J,Ling EA,Dheen ST

更新日期：2015-12-17 00:00:00

abstract：:Carbon monoxide (CO), like other gaseous neuromodulators, has a dual nature as both a toxic gas and a physiologically relevant signaling molecule. In the nervous system, high concentrations of CO can lead to neuronal injury while lower concentrations are found to be neuroprotective. The number of cellular targets affe...

journal_title：Neuroscience

authors： Estes S,Zhong LR,Artinian L,Rehder V

更新日期：2015-12-17 00:00:00

abstract：:Huntington's disease (HD) is a severe genetically inherited neurodegenerative disorder. Patients present with three principal phenotypes of motor symptoms: choreatic, hypokinetic-rigid and mixed. The Q175 mouse model of disease offers an opportunity to investigate the cellular basis of the hypokinetic-rigid form of HD...

journal_title：Neuroscience

authors： Rothe T,Deliano M,Wójtowicz AM,Dvorzhak A,Harnack D,Paul S,Vagner T,Melnick I,Stark H,Grantyn R

更新日期：2015-12-17 00:00:00

abstract：:In rat thalamic paraventricular nucleus of thalamus (PVT) neurons, activation of thyrotropin-releasing hormone (TRH) receptors enhances excitability via concurrent decrease in G protein-coupled inwardly-rectifying potassium (GIRK)-like and activation of transient receptor potential cation (TRPC)4/5-like cationic condu...

journal_title：Neuroscience

authors： Zhang L,Kolaj M,Renaud LP

更新日期：2015-12-17 00:00:00

abstract：:This study aimed to evaluate the effects of repetitive transcranial magnetic stimulation (rTMS) on learning and memory in a rat model of vascular dementia (VaD) and to analyze the associated mechanisms. Bilateral carotid artery occlusion (2-VO) was used to establish a rat model of VaD. High-frequency (5Hz) rTMS was pe...

journal_title：Neuroscience

authors： Zhang N,Xing M,Wang Y,Tao H,Cheng Y

更新日期：2015-12-17 00:00:00

abstract：:The 5-HT6 receptor (5-HT6R) is almost exclusively expressed in the brain and has emerged as a promising target for cognitive disorders, including Alzheimer's disease. In the present study, we have determined the cell types on which the 5-HT6R is expressed by colocalizing 5-HT6R mRNA with that of a range of neuronal an...

journal_title：Neuroscience

authors： Helboe L,Egebjerg J,de Jong IE

更新日期：2015-12-03 00:00:00

abstract：:High-intensity sound can induce seizures in susceptible animals. After repeated acoustic stimuli changes in behavioural seizure repertoire and epileptic EEG activity might be seen in recruited limbic and forebrain structures, a phenomenon known as audiogenic kindling. It is postulated that audiogenic kindling can prod...

journal_title：Neuroscience

authors： Cunha AO,de Oliveira JA,Almeida SS,Garcia-Cairasco N,Leão RM

更新日期：2015-12-03 00:00:00

abstract：:The hypocretin/orexin system regulates, among other things, sleep and energy homeostasis. The system is likely regulated by both homeostatic and circadian mechanisms. Little is known about local differences in the regulation of hypocretin activity. The aim of this study was to establish an optimized peptide quantifica...

journal_title：Neuroscience

authors： Justinussen JL,Holm A,Kornum BR

更新日期：2015-12-03 00:00:00

abstract：:Treatment of Parkinson's disease (PD) with dopamine replacement relieves symptoms of poverty of movement, but often causes drug-induced dyskinesias. Accumulating clinical and pre-clinical evidence suggests that the primary motor cortex (M1) is involved in the pathophysiology of PD and that modulating cortical activity...

journal_title：Neuroscience

authors： Lindenbach D,Conti MM,Ostock CY,Dupre KB,Bishop C

更新日期：2015-12-03 00:00:00

abstract：:Clinical and animal studies indicate that maternal consumption of ethanol during pregnancy increases alcohol drinking in the offspring. Possible underlying mechanisms may involve orexigenic peptides, which are stimulated by prenatal ethanol exposure and themselves promote drinking. Building on evidence that ethanol st...

journal_title：Neuroscience

authors： Chang GQ,Karatayev O,Leibowitz SF

更新日期：2015-12-03 00:00:00

abstract：:The perception of tool-object pairs involves understanding their action-relationships (affordances). Here, we sought to evaluate how an observer visually encodes tool-object affordances. Eye-movements were recorded as right-handed participants freely viewed static, right-handed, egocentric tool-object images across th...

journal_title：Neuroscience

authors： Natraj N,Pella YM,Borghi AM,Wheaton LA

更新日期：2015-12-03 00:00:00

abstract：:Hippocampal anatomy and network organization are capable to generate drug-resistant temporal lobe epilepsy (TLE) in humans and particularly vulnerable to segmental neuronal cell loss. Surgical hippocampectomy has been proven successful in treatment and available human tissue specimens allow systematic clinico-patholog...

journal_title：Neuroscience

authors： Coras R,Blümcke I

更新日期：2015-11-19 00:00:00

abstract：:The hippocampal CA1 region receives cortical information via two main inputs: directly via the perforant (temporoammonic) path (pp-CA1 synapse) and indirectly via the tri-synaptic pathway. Although synaptic plasticity has been reported at the pp-CA1 synapse of freely behaving animals, the mechanisms underlying this ph...

journal_title：Neuroscience

authors： Aksoy-Aksel A,Manahan-Vaughan D

更新日期：2015-11-19 00:00:00

abstract：:For over two decades it has been increasingly appreciated that synaptic plasticity mechanisms are subject to activity-dependent metaplastic regulation. In recent years it has also become apparent that astrocytes are active partners with neurons at synapses, and have the capability to powerfully regulate synaptic plast...

journal_title：Neuroscience

authors： Jones OD

更新日期：2015-11-19 00:00:00

abstract：:One of the most replicated findings has been that hippocampus volume is decreased in patients with major depressive disorder (MDD). Recent volumetric magnetic resonance imaging (MRI) studies suggest that localized differences in hippocampal volume may be more prominent than global differences. Preclinical and post-mor...

journal_title：Neuroscience

authors： Malykhin NV,Coupland NJ

更新日期：2015-11-19 00:00:00

abstract：:Sleep is strongly implicated in learning, especially in the reprocessing of recently acquired memory. Children with intellectual disability (ID) tend to have sleep-wake disturbances, which may contribute to the pathophysiology of the disease. Given that sleep is partly controlled by the circadian clock, we decided to ...

journal_title：Neuroscience

authors： Renaud J,Dumont F,Khelfaoui M,Foisset SR,Letourneur F,Bienvenu T,Khwaja O,Dorseuil O,Billuart P

更新日期：2015-11-12 00:00:00

abstract：:The prairie vole (Microtus ochrogaster) is a socially monogamous rodent species that forms pair bonds after mating. Recent data have shown that amphetamine (AMPH) is rewarding to prairie voles as it induces conditioned place preferences. Further, repeated treatment with AMPH impairs social bonding in adult prairie vol...

journal_title：Neuroscience

authors： Fukushiro DF,Olivera A,Liu Y,Wang Z

更新日期：2015-10-29 00:00:00

abstract：:The blockade of the central nucleus of the amygdala (CeA) with the GABAA receptor agonist muscimol significantly reduces hypertonic NaCl and water intake by sodium-depleted rats. In the present study we investigated the effects of previous injection of losartan, an angiotensin II type-1 (AT1) receptor antagonist, into...

journal_title：Neuroscience

authors： Hu B,Qiao H,Sun B,Jia R,Fan Y,Wang N,Lu B,Yan JQ

更新日期：2015-10-29 00:00:00

abstract：:Our study examined how different housing conditions modulated the acquisition of a spatial reference memory task and also, a reversal task in the 4-radial arm water maze (4-RAWM). The animals were randomly assigned to standard or enriched cages, and, as a type of complementary stimulation along with the environmental ...

journal_title：Neuroscience

authors： Sampedro-Piquero P,Zancada-Menendez C,Begega A

更新日期：2015-10-29 00:00:00

abstract：:Social play is a motivated and rewarding behavior that is displayed by nearly all mammals and peaks in the juvenile period. Moreover, social play is essential for the development of social skills and is impaired in social disorders like autism. We recently showed that the lateral septum (LS) is involved in the regulat...

journal_title：Neuroscience

authors： Bredewold R,Schiavo JK,van der Hart M,Verreij M,Veenema AH

更新日期：2015-10-29 00:00:00

abstract：:In the present study, we investigated whether endoplasmic reticulum (ER) stress is associated with neuronal- and astroglial-death in the hippocampus using LiCl-pilocarpine-induced status epilepticus (SE) rat model. Glucose-related protein (GRP) 78 and protein disulfide isomerase (PDI) expressions were transiently incr...

journal_title：Neuroscience

authors： Ko AR,Kim JY,Hyun HW,Kim JE

更新日期：2015-10-29 00:00:00

abstract：:Sodium-dependent high-affinity amino-acid transporters play crucial roles in terminating synaptic transmission in the central nervous system (CNS). However, there is lack of information about the mechanisms underlying the regulation of amino-acid transport by fast-acting neuromodulators, like ATP. Here, we investigate...

journal_title：Neuroscience

authors： Barros-Barbosa AR,Lobo MG,Ferreirinha F,Correia-de-Sá P,Cordeiro JM

更新日期：2015-10-15 00:00:00

abstract：:In vitro cell cultures are an important tool for obtaining insights into cellular processes in an isolated system and a supplement to in vivo animal experiments. While primary dissociated cultures permit a single homogeneous cell population to be studied, there is a clear need to explore the function of brain cells in...

journal_title：Neuroscience

authors： Humpel C

更新日期：2015-10-01 00:00:00

abstract：:Acidic fibroblast growth factor (aFGF) is a neurotrophic factor which is a powerful neuroprotective and neuroregenerative factor of the nervous system. Prior study had shown that levels of FGFs significantly increase following ischemic injury, reflecting a physiological protection mechanism. However, few reports demon...

journal_title：Neuroscience

authors： Tsai MJ,Tsai SK,Huang MC,Liou DY,Huang SL,Hsieh WH,Huang WC,Huang SS,Cheng H

更新日期：2015-10-01 00:00:00